Visceral obesity and chronic pain: effect of a 4-week rehabilitation program on adipokines and insulin resistance

نویسندگان

  • Florence Doury-Panchout
  • Jean-Charles Metivier
  • Julien Nardoux
  • Bernard Fouquet
چکیده

Obesity and chronic pain are two major diseases of the 21th century. Our principal objective was to investigate the effects of a 4-week rehabilitation program on adiponectin and leptin concentrations, and insulin resistance, in patients with abdominal obesity and chronic pain syndrome. Our secondary objectives were to investigate the effects of this program on pain, body mass index (BMI), waist circumference and maximal oxygen consumption (VO2max) and to compare changes in VO2max between patients with or without insulin resistance. Among a consecutive sample of 128 patients with abdominal obesity hospitalized for rehabilitation for a chronic pain syndrome, 111 completed the protocol, which was a 4-week rehabilitation program including 6 hr of rehabilitation per day, 5 days per week, in a referral center of rehabilitation. This prospective cohort study compared clinical (BMI, waist circumference, VO2max, pain) and biological measures (concentrations of adiponectin, leptin and insulin, score of homeostasis model assessment of insulin resistance [HOMA]) before and after the program. Plasma leptin, adiponectin and insulin concentrations (P<0.0001) and score of HOMA (P=0.0002) had decreased significantly by the end of the 4 weeks. Pain, BMI and waist circumference decreased significantly, and VO2max improved significantly (P=0.0001). Patients with insulin resistance had less improvement of their aerobic condition at the end of the 4 weeks (P<0.002). The rehabilitation program decreases the concentration of leptin, and improves insulin sensitivity in patients with chronic pain and visceral obesity. Aerobic recovery was worse for patients with insulin resistance than other patients.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Aerobic Training Program on Obesity and Insulin Resistance in Young Women with Polycystic Ovary Syndrome

OBJECTIVE: Polycystic Ovary Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age characterized by the presence of polycystic ovaries, menstrual dysfunction and biochemical or clinical hyperandrogenism. Lifestyle modification is important in treatment of obese and overweight women with PCOS. This study was performed to evaluate the benefit of aerobic exercise training o...

متن کامل

The effects of high fat diet-induced obesity and interval and continuous exercise training on visceral fat SIRT1 and insulin resistance in male rats

Introduction. The aim of this study was to investigate the effects of high fat diet-induced obesity and interval and continuous exercise training on visceral fat SIRT1 and insulin resistance in male rats.  Method. Forty male rats were divided into two groups: high-fat diet (HFD; n=32) and standard diet (C; n=8). After 10 weeks inducing obesity, eight rats from the HFD and C groups were sacrifi...

متن کامل

The interactive effect of aerobic-resistance training and estrogen therapy on metabolic syndrome indices and omentin-1

Introduction: Obesity and visceral fat accumulation after menopause are associated with insulin resistance and cardiovascular diseases. We investigated the interactive effect of aerobic-resistance training and estrogen replacement therapy on visceral fat, omentin-1 and HOMA-IR in ovariectomized rats. Materials and Methods: Fifty female Wistar rats were ovariectomized (OVX) and divided into 5 gr...

متن کامل

Effect of Eight-Week High Intensity Interval Training on Omentin-1 Gene Expression and Insulin-Resistance in Diabetic Male Rats

Background. Omentin-1, a novel adipokine expressed in visceral adipose tissue, is negatively correlated with insulin-resistance and obesity. Objective(s). The aim of this study was to investigate the effect of eight weeks of high-intensity interval training on omentin-1 gene expression in visceral adipose tissue and insulin-resistance in male wistar rats. Methods. A total of 26 male Wis...

متن کامل

The Effect of Regular Physical Activities on the Visceral Fat in Diabetic Patients in Iran- Review

Objective: The growing prevalence of diabetes makes this disease a health threatening issue. Regular physical activity is a solution in prevention and treatment of diabetes. Therefore, the aim of the present study was to review the effect of exercise trainings on visceral fat tissue in type 2 diabetes patients, based on the studies performed in Iran. Materials and Methods: The present study is...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 13  شماره 

صفحات  -

تاریخ انتشار 2017